Andrew Lees: Mentored by a Madman: The William Burroughs Experiment

https://www.amazon.fr/Mentored-Madman-William-Burroughs-Experiment/dp/1910749109

In this extraordinary memoir, neuroscientist Andrew Lees explains how William Burroughs, author of Naked Lunch and troubled drug addict, played an unlikely part in his medical career. Lees draws on Burroughs search for an addiction cure to discover a ground-breaking treatment for shaking palsy, and learns how to use the deductive reasoning of Sherlock Holmes to diagnose patients. Lees follows Burroughs into the rainforest and under the influence of yagé (ayahuasca) gains insights that encourage him to pursue new lines of pharmacological research and explore new forms of science.

Available at Notting Hill Editions: http://www.nottinghilleditions.com/authors/andrew-lees/409

Andrew Lees

Andrew Lees is a Professor of Neurology at the National Hospital, London. He is the recipient of numerous awards including the American Academy of Neurology Life Time Achievement Award, the Association of British Neurologist’s Medal, the Dingebauer Prize for outstanding research and the Gowers Medal. He is one of the three most highly cited Parkinson’s disease researchers in the world. He is the author of several books, including Ray of Hope, runner-up in the William Hill Sports Book of the Year and The Silent Plague.
REVIEW OF Mentored by a Madman: the William Burroughs Experiment

Mentored by a Madman. The William Burroughs’s Experiment is a fascinating personal account, by one of the world’s leading neurologists, of his quest to find better treatments for Parkinson’s disease. He takes the reader on an extraordinary journey inside and outside the brain, encompassing the commanding heights of academic neurology and the Amazonian Rain Forests. His deep humanity and honesty shines throughout. The inevitable comparison with late, great Oliver Sacks is entirely just. And Lees’ mentor William Burroughs would be well pleased.” – Raymond Tallis

More at:

https://www.eventbrite.com/e/mentored-by-a-madman-the-william-burroughs-experiment-prof-andrew-lees-tickets-23417904583

http://hqinfo.blogspot.fr/2016/05/mentored-by-madman-wiiliam-burroughs.html

https://www.waterstones.com/book/mentored-by-a-madman/andrew-lees/9781910749104

 

Isabelle Aubert-Baudron: Nouvelles possibilités économiques pour la Grèce dans un cadre de pensée non-aristotélicien

Grèce-Union européenne : des négociations limitées à un cadre de pensée aristotélicien.

Nouvelles possibilités dans un cadre non-aristotélicien.

Conclusion.

A lire :

– Dans le blog Pour une économie non-aristotélicienne

Sur Médiapart

L’île logique et nuit des maths

Bonjour à tous,

soyez les bienvenus à la nuit des maths, samedi 4 juillet à Tours, conférences (Cédric Villani), mathémagie, jonglerie, nombreuses surpises et théâtre scientifique,
L’île logique aura le plaisir d’y donner une représentation de son spectacle de clowns scientifiques, « Pilouface« , spectacle familial tout public à 15h,
ainsi que « Galois Poincaré, mythes et maths » à 22h15, sur les travaux de ces illustres savants.
plus d’infos ici :
http://www.nuitdesmaths.org/presentation/

N’hésitez pas, par ailleurs à nous solliciter pour la semaine de la science qui dure 3 semaines !!!

Aussi, il reste quelques places pour le stage théâtre et sciences que nous organisons en Bretagne les 24 et 25 octobre.

Pour ceux qui n’ont pas vu L’affaire 3.14, nous serons au théâtre de la Reine Blanche le 26 septembre (Paris 18e) et les 15 et 16 octobre à Montpellier.

N’hésitez pas à visionner le petit clip sur le la création théâtrale que nous avons faite avec une classe de 5e autour de leur programme de mathématiques, ce concept peut se décliner de multiples façons adaptées !!
https://www.youtube.com/watch?v=KFNUoj_D5-A

Toute l’équipe vous souhaite un bel été,
caniculairement….

Cédric
www.ilelogique.fr

France Culture (10/06/2015) : Le fléau copié-collé, du secondaire à la thèse

Le thème de l’émission Rue des écoles du 10 juin 2015 :

Le fléau copié-collé, du secondaire à la thèse.

Comment le combattre, le prévenir ? L’épidémie de plagiat doit-elle amener à reconsidérer les objectifs attachés au travail des élèves et des étudiants ?

http://www.franceculture.fr/player/reecouter?play=5046611

Invité, j’interviens à différents moments au cours de l’émission

Jean-Noël Darde

Dans le blog Archéologie du copier-coller: http://archeologie-copier-coller.com/?p=12814

Bruno Dubuc: Lancement du site web Éloge de la suite sur l’œuvre d’Henri Laborit

C’est avec beaucoup de plaisir que je lance aujourd’hui le 21 novembre 2014 le site web Éloge de la suite ( http://www.elogedelasuite.net/ ), date à laquelle Henri Laborit aurait eu 100 ans ! Il s’agit donc d’un site qui tente de rassembler le plus de documents possible autour de l’oeuvre d’Henri Laborit dans le but d’en faire profiter gratuitement le plus grand nombre.

Ce penseur majeur du XXe siècle, multidisciplinaire, innovateur, provocateur et critique féroce de cette société productiviste n’avait pas sa porte d’entrée digne de ce nom dans ce XXIe siècle qui en aurait pourtant bien besoin. Beaucoup de choses sur lui traînent évidemment sur Internet, et ses livres constamment réédités et traduits continuent de faire leur œuvre. Mais comme me le confiait une bibliothécaire lors d’un passage aux Archives Laborit à Paris : « Demandez aux jeunes ici, personnes ne connaît Laborit ».

Or la lecture de ses bouquins m’avait aidé à comprendre bien des choses et à être mieux dans ma peau au début de la vingtaine. C’est cette opportunité que j’aimerais faciliter avec ce site et le projet de film qui vient avec.

Car un film en préparation sur des parcours qui ont croisé Laborit utilise également ce site comme vitrine. Une série de belles rencontres filmées à l’été 2012 dont j’aimerais commencer le montage dans les semaines qui viennent.

Le site web et le projet de film veulent donc montrer comment ces idées sont aujourd’hui incarnées et pourquoi, me semble-t-il, notre époque aurait grand intérêt à mieux les connaître.

Tout comme le film, le site est loin d’être complet et plusieurs sections seront améliorées et enrichies au cours des prochains mois, c’est-à-dire durant l’année 2015 qui marquera également le vingtième anniversaire du décès de Laborit en 1995.

Mais je me devais de sortir aujourd’hui le travail accompli jusqu’ici, question de me soulager d’une vieille dette que je traînais depuis une trentaine d’années…

BRUNO DUBUC

The Guardian: William Burroughs’s drugs cure inspires Alzheimer’s researcher

http://www.theguardian.com/science/2014/oct/26/william-burroughs-drugs-cure-inspires-alzheimers-researcher

Author’s search in South America for the shamans’ plant hallucinogenic yagé and use of apomorphine to control his addiction leads neurologist to call for clinical trials

The Observer, Sunday 26 October 2014

COLOMBIA-NATIVES-YAGE

A shaman starting a yagé ceremony in Colombia. Photograph: Eitan Abramovich/AFP/Getty Images

Alzheimer’s, Parkinson’s and motor neurone disease are the perennial neuro-degenerative afflictions which remind an ageing population that the human brain is still the final frontier of modern medicine.

Now, more than ever, the conundrum of the brain is a profound and fascinating mystery that is inspiring a new generation of graduate neuroscientists and attracting glossy funding for state-of-the-art research. But some of the advances in developing, for example, a cure for Parkinson’s are not hi-tech and have come via unlikely, even exotic, routes. Consider, for instance, the strange tale of Williams Burroughs, “the dead man’s vine” and the British medical establishment.

In 1953 the celebrated author of The Naked Lunch, a countercultural guru and lifelong junkie whose centenary is celebrated this year, travelled to South America on a quest for “the liana of the dead”, the plant source of ayahuasca, also known as yagé, a natural drug whose hallucinogenic properties, used by shamans, had long been known to European explorers. “All agree,” wrote one, “in the account of their sensations under its effects – alterations of cold and heat, fear and boldness, everything joyous and magnificent.”

Burroughs’s quest for “the final fix” was occasionally nerve-racking. After one infusion of yagé, he told his friend, the poet Allen Ginsberg: “I was completely delirious for four hours. The old bastard who prepared this potion specialises in poisoning gringos.”

The trip accelerated Burroughs’s acute drug dependence. In 1956, conscious that he might otherwise die, he went to London to be treated with apomorphine, a non-narcotic derivative of morphine, by Dr John Dent, a medical maverick and coincidentally the secretary of the British Society for the Study of Addiction.

Dent, who had begun his career in 1918 treating drunks around King’s Cross in London, had pioneered the use of apomorphine as a cure for alcoholism, reporting his findings in the British Journal of Inebriety in 1931. Acting on an inspired hunch, Dent applied his treatment to the drug-addicted Burroughs, who reported extraordinary results. “Apomorphine,” he wrote later, “acts on the back brain to normalise the bloodstream in such a way that the enzyme system of addiction is destroyed.”

Burroughs, a languid American beanpole with thin lips and pale blue eyes, attributed his international literary success to Dent’s lifesaving treatment. “At the time I took the apomorphine cure,” he said, “I had no claims to call myself a writer and my creativity was limited to filling a hypodermic. The entire body of work on which my present reputation is based was produced after the apomorphine treatment, and would never have been produced if I had not taken the cure and stayed off junk.”

Soon after Burroughs completed his treatment, Dent’s hunch about apomorphine’s remarkable effect on the addict’s brain was scientifically confirmed. But, perhaps because Dent was an outsider, with many in the medical hierarchy opposed to his radical-empiricist methods, his discovery was never fully adopted as a routine cure for addiction.

There was, however, a new generation of young, anti-establishment, counter-cultural neurologists coming up through the profession. One of these, a young medical student named Andrew Lees, just happened to be a Burroughs aficionado and had become fascinated by the role of apomorphine in curbing the brain’s propensity to addiction.

Today Lees is an internationally renowned professor of neurology at the National Hospital for Neurology and Neurosurgery in London, the author of Alzheimer’s, the Silent Plague (Penguin), and one of Britain’s leading experts in the treatment of both Alzheimer’s and Parkinson’s.

In the 1970s, inspired by Dent and Burroughs, Lees and some colleagues began to experiment with ayahuasca, also exploring the use of apomorphine in neurology, especially in the treatment of Parkinson’s.

“Apomorphine,” Lees told the Observer last week, “is free from narcotic effects and works on the brain by opening the dopamine receptor lock. Burroughs spoke about how it led to enhanced perspective and increased libido.”

At first Lees pioneered his work through self-experimentation. “It was with some trepidation,” he reports, “that I injected myself with 1mg of apomorphine” as the prelude to a fuller clinical investigation.

Later, trials Lees conducted at the Middlesex hospital showed that continuous infusions of apomorphine dramatically alleviated unwanted “switch-offs” (the process whereby patients on long-term L-Dopa treatment suddenly lose the beneficial effects of their medication). As a result, apomorphine became licensed for routine treatment of late-stage Parkinson’s.

Today, however, Lees believes there is an urgent need for more clinical trials: “Drugs like apomorphine should be reinvestigated as an alternative to buprenorphine and methadone in heroin addiction.”

A persistent side-effect of L-Dopa (a naturally occurring amino acid derived from beans) in the treatment of Parkinson’s is its tendency, in a minority of cases, to sponsor addiction with highly disturbing symptoms (binge-eating, obsessive sexual fantasies, reckless gambling, hallucinations and even cross-dressing).

To counter such side-effects, Lees has returned to Burroughs’s accounts of his apomorphine use and says he has found Burroughs’s writing “highly instructive”. Burroughs, for instance, denounces the “vested interests” of the pharmaceutical industry for spending “billions [of dollars] on tranquillisers of dubious value, but not 10 cents for a drug [apomorphine] that has unlimited potential, not only in treating addiction, but in handling the whole problem of anxiety”.

But there is a problem. Where Lees in the 1970s could freely self-experiment at his own risk, new rules and procedures now inhibit this avenue of research. “There’s an urgent need for fresh trials,” says Lees, “in the use of apomorphine for dealing with addiction, but we are up against punitive and draconian legislation. The heroic era of neuropharmacological research has now vanished.”

Lees goes on: “The notion of the investigator as the most ethical first volunteer in clinical trials is now increasingly denigrated by some lawyers and editors of medical journals. Some neuroscientists are being driven underground here.”

Partly from these inhibitions, meanwhile, the use of apomorphine has fallen out of favour. Under-recognised and under-used, the drug that saved Burroughs has become just a curiosity of avant-garde literary life when it could, potentially, become a weapon in the long battle to ameliorate the torments of Britain’s Parkinson’s sufferers.

As Lees says: “Apomorphine has never been fully tested in the way Burroughs advocated.”

On apomorphine cure, Dr John Dent’s life and work:  Apomorphine Versus Addiction Warwick Sweenay’s site (2014)

Dublin Review of Books: Andrew Lees: Hanging Out With The Molecules

http://www.drb.ie/essays/hanging-out-with-the-molecules

Hanging Out With The Molecules

Andrew Lees

The early 1950s voyages of William S Burroughs to Peru led to his discovery of the hallucinogenic vine yagé and issued in a book of notes and letters to his friend Allen Ginsberg in which he presented himself not only as a mystic and spiritual quester but also as a whistleblower on the activities of the Cold War superpowers.

Warwick Sweenay’site: Apomorphine Versus Addiction

http://apomorphineversusaddiction.com

Introduction

Apomorphine Versus Addiction

WAZZER_400

 The purpose of this site  -AvA is educational, devoted to information surrounding the topic of drug dependency that, directly or indirectly, affects us all. All opinions are offered in the non-confrontational spirit of greater understanding, but the facts are commended to science and, in particular, the Humanities.

Anybody is free to comment on any of the issues raised and contribute with info, articles, etc.

It may be of interest to those who strive to reduce the strain on society of addiction that in the 1950s American doctors envied their British counterparts for having escaped, relatively, from the ills that stem from endemic drug use: drug cartels, crime, recidivism,  and a range of socio-economic problems, including poverty, illness and premature death. Sadly, no such distinction can be made today.

The burden of this on society is catastrophic, and, on our health services, crippling. Our legislators have systematically and progressively failed to combat the rise of addiction and continue in denial. Therefore, if you have ever been interested in the political and ethical dimensions surrounding British drugs policy either from a medical, scientific or legislative position, then this site may be of interest to you.

There is no apology for the detail because its concerns are profound and contrast radically with the scant understanding previously directed towards this subject. However, if you are busy, you can start at the  AFTERWORD and refer back to the hyperlinked points.

 

“It is what we think we know that keeps us from learning”
— Claude Bernard, French Physiologist

Henri Laborit: L’inhibition de l’action

Suite à la disparition d’Alain Resnais, voici un extrait de son film “Mon Oncle d’Amérique”, dans lequel Henri Laborit décrit les mécanismes de l’inhibition de l’action.

Henri Laborit, qui était membre de l’Institute of General Semantics ( Henri Laborit: Alfred Korzybski Memorial Lecture 1963: THE NEED FOR GENERALIZATION IN BIOLOGICAL RESEARCH : ROLE OF THE MATHEMATICAL THEORY OF ENSEMBLES http://www.generalsemantics.org/wp-content/uploads/2011/04/gsb-30-31-laborit.pdf ), a appliqué la sémantique générale à ses travaux en biologie.

A noter que les méthodes de harcèlement professionnel ( voir Harcèlement, souffrance au travail, burn out…  , Christophe Dejours: « Evaluation individualisée des performances » et « tournant gestionnaire »   et  Retranscription de l’entretien de Christophe Dejours: « Evaluation individualisée des performances et tournant gestionnaire » ) consistent à placer les gens ciblés dans une situation d’inhibition de l’action, avec pour conséquences, celles décrites par Laborit à la fin de cet extrait.

Mon Oncle d’amerique – Alain Resnais, 1980 (film complet)  de Aurélien Beauvisage

Voir le sommaire et le premier chapitre de son livre La Nouvelle Grille:  Thermodynamique et information  à http://semantiquegenerale.free.fr/Thermodynamique_et_information.pdf .

Chaz Southard: Dreamachine software

Hello everybody,
 
I was introduced to the machine several years ago by a Buddhist poet and have been a member of this group for a fair number of years. During my graduate study, I attempted to make a correlation between mindfulness meditation and the dreammachine.
 
Anyways, I wanted to present this as a lecture to a local art community and decided to create a new user interface for the JavaScript application. Please feel free to share your thoughts on my facelift and pass on app.
 
 
my best,
Chaz


Documentation d’Interzone sur la dreamachine